In the rapidly evolving landscape of data centers and cloud computing, the disaggregation of storage and compute resources has emerged as a critical strategy to enhance scalability and efficiency. This white paper explores how the NVMe over TCP solution that combines the AMD Alveo™ U45N Network Accelerator Card with hardware acceleration engines in the FPGA offers superior performance from offloading compute intense operations, particularly when compared to traditional NIC-based solutions. By leveraging the power of AMD FPGAs and hardware optimized NVMe over a TCP solution, this approach provides significant advantages in performance, scalability, and flexibility.