To close a simulation, in the Vivado IDE:
Select File > Exit or click the X at the top-right corner of the project window.
CAUTION:
When there are multiple simulations running, clicking the X on the blue title bar closes all simulations. To close a single simulation, click the X on the small gray or white tab under the blue title bar.
To close a simulation from the Tcl Console, type:
close_sim The Tcl command first checks for unsaved wave configurations. If it exists, the
command issues an error. Close or save unsaved wave configurations before issuing the close_sim command, or add the -force option to the Tcl command.
Note: It is always recommended to use
close_sim command to completely close the simulation before using close_project command to close the current project.